Good Antioxidant Foods

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But, lycopene within supplement shape doesn’t seem like powerful at lower doses, both.

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“There is a strong [protective] correlation between the intake of [actual whole] fruit[s] and vegetables and the prevalence of sure cancers.” But when we complement with handiest a single compound isolated within tablet shape, we can also dissatisfied the healthful natural stability of antioxidants. It does appear to be pretty the human hubris to assume we can reproduce “the useful consequences of ingesting entire fruits and vegetables” by means of giving dietary supplements of a single phytochemical, which would commonly have interaction with lots of different compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be known “to build up in human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—not to mention all of the compounds we've yet to even represent.

But, it’s not approximately finding the only magic bullet: “The anti-cancer results of carotenoids and other phytonutrients may reside in [their] mixed pastime.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located in the majority who eat everyday amounts of tomatoes, there’s very little effect on most cancers cellular increase in vitro, used one by one.

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But combine all of them together, and a non-powerful dose plus a non-effective dose will become effective in some way, notably suppressing prostate most cancers cell increase.

And, the same synergy can be visible across foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E observed within nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—much less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is extra than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “through 17.5%.” PSA, prostate-particular antigen, is a protein produced by prostate gland cells, and expanded blood ranges are mechanically used “to monitor the achievement of [cancer] treatment.

It was sudden to discover that,” in only three weeks, a “tomato sauce-primarily based nutritional intervention” ought to lower PSA concentrations within guys with prostate most cancers. Also, free radical damage of the DNA in their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-terrible their weight loss plan have to had been beforehand, if much less than a cup of tomato sauce a day ought to reduce DNA harm through more than a 5th.

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Okay, however what did they discover in their prostates? “[H]uman prostate tissue [is thought to] be especially susceptible to oxidative DNA damage by way of loose radicals, which are notion to play a essential position within all ranges of [cancer formation].” This can be for a number of motives, such as “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% less loose radical damage than predicted.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here changed into no affiliation between” the extent of lycopene in the prostate and the protecting outcomes.

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Tomatoes contain an entire bunch of factors, some of which may be even more powerful than lycopene.

Regardless, within contrast to the lycopene supplements alone, “the entire-food intervention” appeared to assist. To see if lycopene played any position in any respect, one might have to test a lycopene-unfastened tomato—within different words, a yellow tomato.

So, what if you in comparison purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a tablet?

So, they fed human beings pink tomato paste, yellow tomato paste, lycopene drugs, or placebo drugs, after which dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to those no longer consuming anything, the purple tomato serum, the blood from individuals who ate crimson tomato paste, significantly decreased the prostate cancer cellular’s expression of a increase-promoting gene called cyclin D1.

This downregulation of the gene by means of the red tomato consumption “may make contributions to decrease prostate cancer chance with the aid of proscribing cellular proliferation.” The crimson tomato regarded to work higher than the yellow;

so, maybe the lycopene helped, however no longer in tablet shape. “[T]his gene became now not regulated by way of [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene on my own significantly upregulated “procarcinogenic genes.

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