Natural Beta Carotene

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But, lycopene in supplement shape doesn’t look like powerful at decrease doses, both.

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“There is a robust [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the occurrence of sure cancers.” But while we complement with handiest a unmarried compound isolated in tablet form, we can also disenchanted the healthy herbal balance of antioxidants. It does appear to be quite the human hubris to suppose we can reproduce “the useful consequences of eating whole fruits and vegetables” by means of giving supplements of a single phytochemical, which might commonly have interaction with heaps of different compounds in “the natural matrix” Mother Nature meant.

In addition to lycopene, different carotenoids within tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be known “to build up within human prostate tissue.” And, “there are also severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] hobby”—not to mention all the compounds we have yet to even represent.

But, it’s now not about finding the only magic bullet: “The anti-most cancers effects of carotenoids and different phytonutrients may additionally live within [their] mixed interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within most people who eat regular quantities of tomatoes, there’s very little effect on most cancers cellular boom within vitro, used one at a time.

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But combine all of them collectively, and a non-powerful dose plus a non-effective dose turns into effective someway, appreciably suppressing prostate most cancers mobile growth.

And, the identical synergy may be visible across meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E located in nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The entire is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “by 17.5%.” PSA, prostate-particular antigen, is a protein produced via prostate gland cells, and extended blood levels are routinely used “to reveal the success of [cancer] remedy.

It became sudden to discover that,” in just three weeks, a “tomato sauce-based totally dietary intervention” may want to lower PSA concentrations in guys with prostate cancer. Also, loose radical damage of the DNA in their white blood cells dropped with the aid of 21%.

Imagine how antioxidant-poor their food plan must had been in advance, if much less than a cup of tomato sauce a day should lessen DNA harm with the aid of more than a 5th.

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Okay, but what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be specifically susceptible to oxidative DNA damage via loose radicals, that are notion to play a vital role within all tiers of [cancer formation].” This can be for a number of motives, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical damage than anticipated.

Here’s the DNA harm inside the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here turned into no affiliation between” the level of lycopene in the prostate and the protecting consequences.

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Tomatoes incorporate an entire bunch of things, a number of which may be even more powerful than lycopene.

Regardless, within assessment to the lycopene dietary supplements by myself, “the entire-meals intervention” appeared to assist. To see if lycopene played any position in any respect, one would have to check a lycopene-unfastened tomato—within different words, a yellow tomato.

So, what in case you in comparison crimson tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed people pink tomato paste, yellow tomato paste, lycopene pills, or placebo capsules, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones now not eating some thing, the purple tomato serum, the blood from people who ate purple tomato paste, significantly decreased the prostate cancer cell’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene by the pink tomato intake “may additionally make contributions to decrease prostate most cancers danger by proscribing cell proliferation.” The crimson tomato regarded to paintings better than the yellow;

so, perhaps the lycopene helped, however now not in pill shape. “[T]his gene was not regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone significantly upregulated “procarcinogenic genes.

Natural Beta-Carotene/ Mixed Carotenoids