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But, lycopene in complement form doesn’t look like effective at lower doses, both.

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“There is a sturdy [protective] correlation among the consumption of [actual whole] fruit[s] and veggies and the prevalence of certain cancers.” But when we complement with only a unmarried compound remoted in pill shape, we may also disenchanted the healthful natural balance of antioxidants. It does seem to be pretty the human hubris to assume we can reproduce “the beneficial results of ingesting complete culmination and veggies” with the aid of giving dietary supplements of a unmarried phytochemical, which could commonly interact with lots of different compounds in “the herbal matrix” Mother Nature meant.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be known “to accumulate within human prostate tissue.” And, “there are also severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—not to say all of the compounds we've yet to even symbolize.

But, it’s now not about locating the only magic bullet: “The anti-cancer results of carotenoids and other phytonutrients can also are living within [their] blended activity.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within the majority who consume regular quantities of tomatoes, there’s very little impact on most cancers mobile increase in vitro, used separately.

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But combine all of them together, and a non-powerful dose plus a non-effective dose becomes powerful somehow, notably suppressing prostate most cancers cell increase.

And, the identical synergy can be visible across meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E determined within nuts and seeds do little to inhibit seasoned-growth signaling of prostate most cancers cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “by way of 17.5%.” PSA, prostate-particular antigen, is a protein produced by means of prostate gland cells, and multiplied blood stages are mechanically used “to reveal the achievement of [cancer] treatment.

It was surprising to find that,” in just three weeks, a “tomato sauce-based totally nutritional intervention” may want to decrease PSA concentrations within men with prostate most cancers. Also, loose radical damage of the DNA of their white blood cells dropped through 21%.

Imagine how antioxidant-bad their food plan need to were ahead, if much less than a cup of tomato sauce an afternoon should lessen DNA harm by using greater than a fifth.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be particularly prone to oxidative DNA harm through loose radicals, which are concept to play a crucial position in all degrees of [cancer formation].” This may be for some of motives, which includes “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented patients had 28% less unfastened radical damage than anticipated.

Here’s the DNA harm in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]here become no association between” the extent of lycopene within the prostate and the protective consequences.

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Tomatoes include an entire bunch of things, some of which may be even greater effective than lycopene.

Regardless, within assessment to the lycopene supplements alone, “the whole-food intervention” seemed to assist. To see if lycopene performed any function at all, one would have to check a lycopene-free tomato—within other phrases, a yellow tomato.

So, what if you compared purple tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to instantly lycopene within a tablet?

So, they fed human beings pink tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, after which dripped their blood on prostate cancer cells developing in a petri dish.

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Compared to those not ingesting some thing, the crimson tomato serum, the blood from folks who ate red tomato paste, significantly reduced the prostate most cancers mobile’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene via the purple tomato intake “may make a contribution to decrease prostate cancer danger through proscribing mobile proliferation.” The pink tomato appeared to paintings better than the yellow;

so, perhaps the lycopene helped, however now not in tablet form. “[T]his gene become no longer regulated by way of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene by myself appreciably upregulated “procarcinogenic genes.

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