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But, lycopene in supplement shape doesn’t seem like effective at decrease doses, both.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the occurrence of certain cancers.” But when we complement with only a unmarried compound remoted within pill form, we may additionally disillusioned the wholesome natural balance of antioxidants. It does seem to be quite the human hubris to assume we will reproduce “the useful consequences of ingesting complete end result and greens” with the aid of giving dietary supplements of a unmarried phytochemical, which would normally engage with hundreds of different compounds in “the natural matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which are regarded “to build up within human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] interest”—no longer to mention all of the compounds we've but to even signify.

But, it’s now not approximately finding the only magic bullet: “The anti-cancer effects of carotenoids and other phytonutrients may additionally are living within [their] combined interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene located within the majority who eat ordinary quantities of tomatoes, there’s very little impact on most cancers cellular boom within vitro, used one by one.

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But combine them all together, and a non-powerful dose plus a non-effective dose turns into powerful by some means, substantially suppressing prostate most cancers cell boom.

And, the equal synergy can be seen throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E observed in nuts and seeds do little to inhibit seasoned-growth signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The complete is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “with the aid of 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and accelerated blood levels are automatically used “to screen the fulfillment of [cancer] treatment.

It changed into surprising to discover that,” in only three weeks, a “tomato sauce-based dietary intervention” ought to decrease PSA concentrations in men with prostate most cancers. Also, free radical damage of the DNA of their white blood cells dropped by way of 21%.

Imagine how antioxidant-terrible their food plan ought to were ahead, if less than a cup of tomato sauce an afternoon may want to lessen DNA harm by more than a 5th.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be specially prone to oxidative DNA damage by using free radicals, which are notion to play a crucial role in all stages of [cancer formation].” This may be for a number of reasons, inclusive of “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical harm than anticipated.

Here’s the DNA harm in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here become no affiliation among” the extent of lycopene within the prostate and the protecting effects.

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Tomatoes contain a whole bunch of things, some of which may be even extra powerful than lycopene.

Regardless, in evaluation to the lycopene supplements on my own, “the entire-food intervention” appeared to assist. To see if lycopene played any position in any respect, one could have to test a lycopene-loose tomato—in other phrases, a yellow tomato.

So, what if you as compared crimson tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to immediately lycopene within a pill?

So, they fed human beings red tomato paste, yellow tomato paste, lycopene capsules, or placebo tablets, and then dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to the ones not ingesting something, the red tomato serum, the blood from individuals who ate crimson tomato paste, extensively reduced the prostate cancer mobile’s expression of a boom-selling gene called cyclin D1.

This downregulation of the gene by means of the purple tomato consumption “might also contribute to decrease prostate cancer chance by using limiting cell proliferation.” The red tomato appeared to paintings higher than the yellow;

so, maybe the lycopene helped, but no longer in pill form. “[T]his gene became now not regulated by [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own notably upregulated “procarcinogenic genes.

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