Protein Supplements

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But, lycopene in supplement form doesn’t look like effective at lower doses, both.

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“There is a robust [protective] correlation between the intake of [actual whole] fruit[s] and veggies and the incidence of positive cancers.” But whilst we supplement with best a unmarried compound isolated within pill form, we may additionally dissatisfied the healthful herbal balance of antioxidants. It does seem to be quite the human hubris to suppose we will reproduce “the useful results of consuming entire end result and vegetables” by giving supplements of a single phytochemical, which would usually have interaction with heaps of different compounds in “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be regarded “to build up within human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] activity”—now not to mention all the compounds we've yet to even represent.

But, it’s now not approximately locating the only magic bullet: “The anti-most cancers results of carotenoids and other phytonutrients might also reside in [their] combined interest.” For example, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found within the general public who devour ordinary quantities of tomatoes, there’s very little impact on most cancers mobile growth in vitro, used one by one.

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But combine all of them together, and a non-effective dose plus a non-effective dose becomes powerful someway, significantly suppressing prostate most cancers cellular increase.

And, the identical synergy can be seen throughout meals. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E determined in nuts and seeds do little to inhibit pro-increase signaling of prostate cancer cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The complete is extra than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” have been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “with the aid of 17.5%.” PSA, prostate-specific antigen, is a protein produced through prostate gland cells, and expanded blood ranges are routinely used “to display the fulfillment of [cancer] treatment.

It was sudden to discover that,” in just three weeks, a “tomato sauce-based totally dietary intervention” could decrease PSA concentrations within men with prostate most cancers. Also, free radical damage of the DNA of their white blood cells dropped through 21%.

Imagine how antioxidant-terrible their food regimen must have been ahead, if much less than a cup of tomato sauce an afternoon may want to reduce DNA damage by using greater than a fifth.

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Okay, but what did they find in their prostates? “[H]uman prostate tissue [is thought to] be specifically liable to oxidative DNA harm with the aid of unfastened radicals, that are concept to play a critical position in all stages of [cancer formation].” This may be for a number of motives, which includes “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% much less loose radical harm than expected.

Here’s the DNA damage within the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here was no association among” the extent of lycopene within the prostate and the protective outcomes.

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Tomatoes incorporate an entire bunch of things, a number of which may be even extra effective than lycopene.

Regardless, in evaluation to the lycopene dietary supplements on my own, “the whole-meals intervention” regarded to assist. To see if lycopene played any function in any respect, one could have to check a lycopene-free tomato—in different phrases, a yellow tomato.

So, what in case you in comparison pink tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to instantly lycopene within a tablet?

So, they fed humans red tomato paste, yellow tomato paste, lycopene tablets, or placebo capsules, and then dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to the ones no longer eating whatever, the red tomato serum, the blood from folks who ate pink tomato paste, appreciably decreased the prostate cancer mobile’s expression of a boom-promoting gene referred to as cyclin D1.

This downregulation of the gene through the pink tomato intake “can also make a contribution to decrease prostate cancer hazard through limiting cellular proliferation.” The purple tomato seemed to paintings better than the yellow;

so, perhaps the lycopene helped, however now not in pill form. “[T]his gene was now not regulated by means of [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene on my own substantially upregulated “procarcinogenic genes.

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