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They have been basically denied, with the FDA pronouncing that the proof become “very limited and preliminary,” with out a endorsement allowed for ketchup or dietary supplements.

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By that time, similarly population reports had forged doubt at the lycopene concept. Consumers of high dietary intakes of lycopene didn’t appear to have decrease cancer rates, in any case.

But, who has high nutritional intakes of lycopene?

Those that consume the maximum pizza; so, perhaps it’s no surprise there are blended effects.

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What we want is to place lycopene to the test.

It began with a case study. A 62-yr antique man with terminal prostate cancer;

failed surgery, failed chemotherapy, metastases all over, spread to the bone.

And so, he become sent to hospice to die.

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So, he took it upon himself to initiate “phytotherapy”—plant-primarily based remedy, taking the amount of lycopene located in 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a degree of tumor bulk, began out at 365, dropped to 140 the subsequent month, and then right down to 8.

His metastases began disappearing, and, as of his closing follow-up, regarded to be residing fortunately ever after. But, whilst given in better-dose tablet form, it didn’t seem to paintings.

A 2013 evaluation of all such lycopene supplement trials “did not assist [the initial] optimism.” In fact, they were simply satisfied that the lycopene pills didn’t end up inflicting greater most cancers, like beta-carotene pills did.

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But, then came 2014. Researchers in Italy have been giving the most important doses they may of lycopene, selenium, and isolated green tea compounds to men with precancerous prostate lesions, hoping they might save you full-blown most cancers.

But, in 2014, the expanded effects of a similar trial were posted, in which selenium and nutrition E supplements led to extra most cancers.

Yikes! So, those researchers stopped their trial, and broke the code to unblind the outcomes, And indeed, those taking excessive doses of lycopene, inexperienced tea catechins, and selenium regarded to get greater cancer than people who just got sugar capsules.

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“The potential implications are dramatic,” stated the lead researcher, “given the current large global use of such compounds as alleged preventive vitamins in prostate and other cancers.” What went wrong?

Well, after the beta-carotene pill debacle, researchers measured cellular harm at extraordinary herbal and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed cellular damage, but at higher, supplemental doses, it not handiest regarded to forestall working, however brought about more damage.

And, the equal with lycopene.

“Both lycopene and [beta]-carotene afforded protection against DNA harm” on the varieties of tiers one may see in humans ingesting lots of tomatoes or sweet potatoes—”levels…comparable with the ones seen in the [blood] of folks that eat a carotenoid-wealthy wholesome weight loss program.” However, at the kind of blood concentrations that one might get taking tablets, “the capacity to shield the cells towards such [free radical] harm became rapidly lost, and, certainly, the presence of [high levels of beta-carotene and lycopene] may sincerely serve to boom the quantity of DNA damage.” So, no wonder excessive-dose lycopene pills didn’t paintings.

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“Phytochemicals [may be] guardians of our health,” but “[t]he protection of eating focused extracts…is unknown.” The defensive blessings of a phytochemical-wealthy food plan is high-quality acquired [through whole plant foods].” The food enterprise has exceptional thoughts, although.