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But, lycopene within supplement form doesn’t seem like effective at lower doses, either.

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“There is a robust [protective] correlation among the consumption of [actual whole] fruit[s] and vegetables and the incidence of certain cancers.” But when we supplement with best a unmarried compound isolated in tablet form, we may additionally disappointed the wholesome natural stability of antioxidants. It does appear to be quite the human hubris to assume we can reproduce “the useful effects of consuming whole fruits and vegetables” by means of giving supplements of a unmarried phytochemical, which would generally engage with lots of different compounds within “the natural matrix” Mother Nature intended.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be acknowledged “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—now not to mention all the compounds we've got but to even symbolize.

But, it’s no longer about finding the one magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients may additionally are living in [their] blended hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found in most people who consume regular quantities of tomatoes, there’s little or no effect on most cancers mobile boom in vitro, used separately.

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But integrate all of them collectively, and a non-powerful dose plus a non-effective dose becomes effective in some way, significantly suppressing prostate most cancers cellular increase.

And, the equal synergy may be visible throughout foods. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the vitamin E located within nuts and seeds do little to inhibit seasoned-boom signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The complete is more than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “through 17.5%.” PSA, prostate-unique antigen, is a protein produced with the aid of prostate gland cells, and increased blood tiers are mechanically used “to reveal the fulfillment of [cancer] treatment.

It turned into surprising to locate that,” in only three weeks, a “tomato sauce-primarily based nutritional intervention” may want to decrease PSA concentrations in guys with prostate cancer. Also, unfastened radical harm of the DNA in their white blood cells dropped via 21%.

Imagine how antioxidant-bad their weight loss program should had been ahead, if less than a cup of tomato sauce a day should lessen DNA damage by greater than a 5th.

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Okay, however what did they find of their prostates? “[H]uman prostate tissue [is thought to] be mainly prone to oxidative DNA harm by unfastened radicals, which can be notion to play a critical function in all stages of [cancer formation].” This can be for some of motives, which include “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% much less free radical harm than expected.

Here’s the DNA damage in the prostate before the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here changed into no association between” the level of lycopene inside the prostate and the protecting effects.

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Tomatoes contain an entire bunch of things, some of which can be even more powerful than lycopene.

Regardless, in evaluation to the lycopene supplements alone, “the entire-meals intervention” seemed to assist. To see if lycopene played any position at all, one might have to test a lycopene-free tomato—in different phrases, a yellow tomato.

So, what in case you compared crimson tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed human beings purple tomato paste, yellow tomato paste, lycopene pills, or placebo capsules, after which dripped their blood on prostate cancer cells growing in a petri dish.

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Compared to the ones no longer eating something, the pink tomato serum, the blood from individuals who ate red tomato paste, drastically decreased the prostate most cancers cellular’s expression of a boom-selling gene called cyclin D1.

This downregulation of the gene by using the pink tomato intake “may make contributions to decrease prostate cancer risk by restricting cell proliferation.” The red tomato regarded to paintings higher than the yellow;

so, perhaps the lycopene helped, but no longer in tablet shape. “[T]his gene was not regulated by using [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene on my own drastically upregulated “procarcinogenic genes.

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