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But, lycopene in supplement form doesn’t appear like powerful at lower doses, either.

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“There is a sturdy [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the prevalence of positive cancers.” But when we complement with best a single compound isolated in pill shape, we may dissatisfied the healthy herbal balance of antioxidants. It does seem to be quite the human hubris to assume we will reproduce “the useful results of ingesting complete end result and vegetables” through giving dietary supplements of a single phytochemical, which could usually engage with lots of other compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognized “to build up in human prostate tissue.” And, “there also are numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to say all of the compounds we've yet to even characterize.

But, it’s not approximately locating the only magic bullet: “The anti-most cancers results of carotenoids and other phytonutrients might also reside within [their] mixed pastime.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found in the general public who devour ordinary amounts of tomatoes, there’s very little effect on cancer cell growth within vitro, used one at a time.

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But integrate them all together, and a non-effective dose plus a non-effective dose will become effective by some means, considerably suppressing prostate cancer cell growth.

And, the same synergy may be visible across foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the diet E located in nuts and seeds do little to inhibit pro-increase signaling of prostate cancer cells—less than 10%.

But all three together suppresses increase signaling like 70%.

The whole is greater than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “with the aid of 17.5%.” PSA, prostate-precise antigen, is a protein produced by using prostate gland cells, and improved blood levels are automatically used “to reveal the achievement of [cancer] treatment.

It become unexpected to locate that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” should lower PSA concentrations in men with prostate most cancers. Also, unfastened radical damage of the DNA in their white blood cells dropped by way of 21%.

Imagine how antioxidant-bad their weight loss program ought to have been beforehand, if less than a cup of tomato sauce an afternoon may want to reduce DNA harm by means of extra than a 5th.

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Okay, but what did they find of their prostates? “[H]uman prostate tissue [is thought to] be mainly at risk of oxidative DNA damage through loose radicals, which can be concept to play a critical role within all levels of [cancer formation].” This may be for a number of motives, which includes “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% much less free radical harm than predicted.

Here’s the DNA harm in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here become no affiliation among” the extent of lycopene within the prostate and the protecting effects.

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Tomatoes incorporate a whole bunch of factors, a number of which may be even more powerful than lycopene.

Regardless, in comparison to the lycopene dietary supplements alone, “the entire-meals intervention” appeared to assist. To see if lycopene played any role at all, one could have to test a lycopene-loose tomato—within other words, a yellow tomato.

So, what in case you compared crimson tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene capsules, or placebo capsules, after which dripped their blood on prostate most cancers cells developing in a petri dish.

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Compared to the ones now not eating some thing, the pink tomato serum, the blood from folks who ate crimson tomato paste, significantly reduced the prostate cancer cell’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene with the aid of the pink tomato consumption “may also make a contribution to decrease prostate most cancers threat by restricting mobile proliferation.” The pink tomato appeared to work higher than the yellow;

so, perhaps the lycopene helped, however no longer within tablet shape. “[T]his gene became now not regulated through [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene by myself notably upregulated “procarcinogenic genes.

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