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But, lycopene within complement form doesn’t appear to be effective at decrease doses, either.

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“There is a sturdy [protective] correlation between the intake of [actual whole] fruit[s] and veggies and the incidence of certain cancers.” But when we supplement with handiest a unmarried compound remoted in pill shape, we may disillusioned the wholesome herbal balance of antioxidants. It does appear to be pretty the human hubris to think we are able to reproduce “the beneficial effects of consuming whole fruits and greens” by giving dietary supplements of a unmarried phytochemical, which could generally interact with hundreds of different compounds within “the natural matrix” Mother Nature meant.

In addition to lycopene, other carotenoids within tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognized “to accumulate within human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—not to mention all the compounds we've got but to even symbolize.

But, it’s not approximately locating the one magic bullet: “The anti-most cancers consequences of carotenoids and other phytonutrients may additionally live within [their] mixed hobby.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene discovered within most of the people who devour normal quantities of tomatoes, there’s little or no effect on cancer cell boom within vitro, used one after the other.

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But integrate all of them collectively, and a non-effective dose plus a non-powerful dose becomes effective by hook or by crook, drastically suppressing prostate cancer mobile increase.

And, the equal synergy may be seen across ingredients. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E observed in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses increase signaling like 70%.

The whole is greater than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “through 17.5%.” PSA, prostate-precise antigen, is a protein produced by way of prostate gland cells, and improved blood tiers are automatically used “to reveal the success of [cancer] remedy.

It turned into unexpected to find that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” ought to decrease PSA concentrations in guys with prostate cancer. Also, unfastened radical damage of the DNA in their white blood cells dropped by using 21%.

Imagine how antioxidant-poor their diet must had been in advance, if less than a cup of tomato sauce a day may want to lessen DNA harm through greater than a 5th.

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Okay, however what did they find in their prostates? “[H]uman prostate tissue [is thought to] be particularly prone to oxidative DNA harm by means of unfastened radicals, which might be thought to play a important role in all tiers of [cancer formation].” This can be for a number of motives, along with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical harm than anticipated.

Here’s the DNA harm within the prostate earlier than the tomato sauce, and here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]here became no association between” the extent of lycopene inside the prostate and the protecting results.

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Tomatoes incorporate a whole bunch of things, a number of which may be even greater powerful than lycopene.

Regardless, within comparison to the lycopene dietary supplements on my own, “the whole-food intervention” appeared to help. To see if lycopene played any role in any respect, one might have to check a lycopene-unfastened tomato—within different words, a yellow tomato.

So, what in case you in comparison crimson tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to immediately lycopene in a pill?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene pills, or placebo pills, and then dripped their blood on prostate cancer cells developing within a petri dish.

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Compared to the ones now not eating anything, the crimson tomato serum, the blood from people who ate purple tomato paste, considerably reduced the prostate most cancers mobile’s expression of a increase-selling gene called cyclin D1.

This downregulation of the gene via the red tomato intake “may make a contribution to decrease prostate most cancers danger by means of restricting cell proliferation.” The pink tomato seemed to paintings better than the yellow;

so, maybe the lycopene helped, however now not in tablet form. “[T]his gene changed into now not regulated through [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone notably upregulated “procarcinogenic genes.

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