Beta Carotene Vitamin

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But, lycopene in complement shape doesn’t appear like effective at decrease doses, either.

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“There is a strong [protective] correlation among the intake of [actual whole] fruit[s] and veggies and the occurrence of certain cancers.” But whilst we supplement with best a unmarried compound isolated within pill shape, we may additionally dissatisfied the healthful natural stability of antioxidants. It does appear to be quite the human hubris to assume we will reproduce “the beneficial outcomes of consuming entire fruits and vegetables” by using giving dietary supplements of a single phytochemical, which might commonly engage with hundreds of different compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be acknowledged “to build up within human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—not to say all of the compounds we've got yet to even signify.

But, it’s no longer about locating the one magic bullet: “The anti-most cancers results of carotenoids and other phytonutrients can also are living in [their] combined pastime.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within most of the people who devour everyday quantities of tomatoes, there’s little or no effect on cancer mobile boom in vitro, used separately.

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But combine all of them together, and a non-effective dose plus a non-effective dose becomes effective somehow, extensively suppressing prostate most cancers cell growth.

And, the identical synergy may be seen throughout foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the nutrition E discovered in nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses growth signaling like 70%.

The whole is more than the sum of its parts.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “with the aid of 17.5%.” PSA, prostate-particular antigen, is a protein produced by using prostate gland cells, and elevated blood degrees are routinely used “to screen the success of [cancer] treatment.

It changed into surprising to find that,” in just three weeks, a “tomato sauce-primarily based nutritional intervention” should lower PSA concentrations in guys with prostate cancer. Also, loose radical harm of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-negative their eating regimen have to have been ahead, if less than a cup of tomato sauce an afternoon could reduce DNA damage with the aid of extra than a 5th.

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Okay, but what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be especially liable to oxidative DNA damage with the aid of free radicals, which are idea to play a critical position in all levels of [cancer formation].” This can be for a number of motives, such as “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented sufferers had 28% much less unfastened radical damage than predicted.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here was no association between” the extent of lycopene within the prostate and the protecting outcomes.

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Tomatoes incorporate a whole bunch of things, some of which can be even extra effective than lycopene.

Regardless, in contrast to the lycopene supplements alone, “the complete-food intervention” regarded to assist. To see if lycopene played any position in any respect, one could have to test a lycopene-free tomato—in other words, a yellow tomato.

So, what in case you compared crimson tomatoes to yellow tomatoes, that have all the non-lycopene tomato compounds, to instantly lycopene in a tablet?

So, they fed humans pink tomato paste, yellow tomato paste, lycopene capsules, or placebo drugs, and then dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to those not eating whatever, the red tomato serum, the blood from folks that ate red tomato paste, notably decreased the prostate cancer cell’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene via the red tomato consumption “may additionally make a contribution to decrease prostate most cancers risk by way of restricting mobile proliferation.” The pink tomato appeared to paintings higher than the yellow;

so, perhaps the lycopene helped, but not within pill form. “[T]his gene become now not regulated by using [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own significantly upregulated “procarcinogenic genes.

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