Carotenoid Lycopene

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But, lycopene in supplement shape doesn’t seem like effective at decrease doses, both.

Carotenoid Lycopene

“There is a robust [protective] correlation between the consumption of [actual whole] fruit[s] and vegetables and the occurrence of sure cancers.” But when we supplement with best a unmarried compound isolated within tablet shape, we may additionally disillusioned the wholesome natural balance of antioxidants. It does seem to be quite the human hubris to assume we will reproduce “the beneficial effects of consuming complete fruits and vegetables” via giving dietary supplements of a single phytochemical, which might typically interact with thousands of other compounds within “the herbal matrix” Mother Nature meant.

In addition to lycopene, different carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are known “to accumulate within human prostate tissue.” And, “there are also numerous non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—not to mention all of the compounds we've but to even characterize.

But, it’s not approximately locating the only magic bullet: “The anti-cancer effects of carotenoids and other phytonutrients may live in [their] mixed interest.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene found in most of the people who consume ordinary amounts of tomatoes, there’s little or no effect on cancer mobile boom in vitro, used one after the other.

Carotenoid Lycopene Benefits

But combine all of them collectively, and a non-powerful dose plus a non-powerful dose will become effective someway, notably suppressing prostate most cancers cell increase.

And, the same synergy may be seen throughout foods. Curcumin, the yellow pigment in turmeric and curry powder, tomato extracts, and the vitamin E determined within nuts and seeds do little to inhibit pro-boom signaling of prostate cancer cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The whole is more than the sum of its elements.

Carotenoid Lycopene In Tomato

So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce every day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “by 17.5%.” PSA, prostate-unique antigen, is a protein produced through prostate gland cells, and increased blood levels are mechanically used “to screen the success of [cancer] treatment.

It turned into sudden to discover that,” in just three weeks, a “tomato sauce-primarily based dietary intervention” ought to decrease PSA concentrations in guys with prostate most cancers. Also, free radical damage of the DNA of their white blood cells dropped by means of 21%.

Imagine how antioxidant-terrible their weight loss plan ought to had been ahead, if less than a cup of tomato sauce a day could lessen DNA harm by means of greater than a 5th.

Carotenoid Pigment Lycopene

Okay, however what did they locate of their prostates? “[H]uman prostate tissue [is thought to] be mainly at risk of oxidative DNA damage by using free radicals, that are idea to play a important position within all levels of [cancer formation].” This can be for a number of reasons, along with “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical treatment, and resected tissues from tomato sauce-supplemented patients had 28% less free radical harm than predicted.

Here’s the DNA damage within the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s thrilling is that “[t]right here turned into no association among” the level of lycopene in the prostate and the protective outcomes.

Carotenoid Antioxidant Lycopene

Tomatoes comprise a whole bunch of factors, a number of which may be even greater effective than lycopene.

Regardless, within evaluation to the lycopene dietary supplements by myself, “the entire-food intervention” regarded to help. To see if lycopene performed any function at all, one could have to check a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you in comparison purple tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to immediately lycopene in a tablet?

So, they fed people crimson tomato paste, yellow tomato paste, lycopene tablets, or placebo drugs, and then dripped their blood on prostate cancer cells developing within a petri dish.

Carotenoid Isomerase Lycopene

Compared to those now not ingesting anything, the red tomato serum, the blood from folks that ate red tomato paste, appreciably reduced the prostate most cancers mobile’s expression of a increase-selling gene referred to as cyclin D1.

This downregulation of the gene by way of the purple tomato intake “may contribute to decrease prostate cancer risk via restricting mobile proliferation.” The crimson tomato appeared to paintings better than the yellow;

so, perhaps the lycopene helped, but no longer in pill shape. “[T]his gene changed into not regulated by [the lycopene-pill serum],” indicating that maybe it’s something else.

And, lycopene by myself significantly upregulated “procarcinogenic genes.

Carotenoid Phytonutrient Lycopene