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They have been essentially denied, with the FDA pronouncing that the proof was “very restricted and initial,” and not using a endorsement allowed for ketchup or supplements.

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By that time, in addition population studies had forged doubt at the lycopene idea. Consumers of excessive dietary intakes of lycopene didn’t seem to have decrease most cancers rates, after all.

But, who has excessive dietary intakes of lycopene?

Those that eat the most pizza; so, perhaps it’s no marvel there are combined effects.

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What we need is to position lycopene to the test.

It commenced with a case poll. A 62-year vintage guy with terminal prostate cancer;

failed surgical operation, failed chemotherapy, metastases all over, unfold to the bone.

And so, he turned into sent to hospice to die.

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So, he took it upon himself to provoke “phytotherapy”—plant-based remedy, taking the quantity of lycopene observed in a quarter-cup of tomato sauce, or a tablespoon of tomato paste every day.

His PSA, a degree of tumor bulk, began out at 365, dropped to 140 the next month, and then down to 8.

His metastases began disappearing, and, as of his final comply with-up, seemed to be dwelling happily ever after. But, when given in better-dose pill form, it didn’t seem to work.

A 2013 review of all such lycopene complement trials “did not aid [the initial] optimism.” In truth, they have been simply happy that the lycopene pills didn’t end up inflicting more cancer, like beta-carotene pills did.

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But, then came 2014. Researchers within Italy have been giving the biggest doses they may of lycopene, selenium, and remoted inexperienced tea compounds to men with precancerous prostate lesions, hoping they could prevent complete-blown cancer.

But, within 2014, the expanded results of a similar trial have been published, wherein selenium and vitamin E dietary supplements ended in greater most cancers.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the outcomes, And certainly, the ones taking excessive doses of lycopene, inexperienced tea catechins, and selenium regarded to get extra most cancers than folks who just were given sugar pills.

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“The capacity implications are dramatic,” said the lead researcher, “given the contemporary huge worldwide use of such compounds as alleged preventive vitamins in prostate and different cancers.” What went incorrect?

Well, after the beta-carotene pill debacle, researchers measured cell damage at exclusive herbal and unnatural doses of beta-carotene. At dietary doses, beta-carotene suppressed cellular harm, however at higher, supplemental doses, it now not only regarded to stop working, however prompted greater damage.

And, the same with lycopene.

“Both lycopene and [beta]-carotene afforded protection towards DNA harm” at the sorts of stages one may see in people eating masses of tomatoes or candy potatoes—”levels…similar with those visible within the [blood] of folks who eat a carotenoid-wealthy wholesome food regimen.” However, on the kind of blood concentrations that one may get taking drugs, “the capability to guard the cells against such [free radical] damage was unexpectedly lost, and, certainly, the presence of [high levels of beta-carotene and lycopene] may additionally simply serve to growth the volume of DNA harm.” So, no marvel excessive-dose lycopene drugs didn’t work.

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“Phytochemicals [may be] guardians of our health,” but “[t]he safety of consuming focused extracts…is unknown.” The shielding advantages of a phytochemical-wealthy weight-reduction plan is satisfactory obtained [through whole plant foods].” The food enterprise has unique ideas, though.