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But, lycopene in supplement form doesn’t look like effective at decrease doses, either.

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“There is a strong [protective] correlation among the consumption of [actual whole] fruit[s] and greens and the incidence of sure cancers.” But whilst we supplement with only a unmarried compound isolated within pill form, we may disenchanted the healthy herbal stability of antioxidants. It does seem to be quite the human hubris to suppose we can reproduce “the beneficial outcomes of consuming entire fruits and vegetables” with the aid of giving supplements of a single phytochemical, which could commonly have interaction with thousands of other compounds in “the herbal matrix” Mother Nature intended.

In addition to lycopene, other carotenoids in tomatoes include beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which might be recognized “to accumulate within human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] activity”—no longer to say all the compounds we've but to even represent.

But, it’s not approximately finding the one magic bullet: “The anti-most cancers outcomes of carotenoids and different phytonutrients may additionally reside in [their] mixed interest.” For example, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed within the general public who consume regular quantities of tomatoes, there’s little or no effect on most cancers cell boom in vitro, used one at a time.

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But integrate them all together, and a non-effective dose plus a non-powerful dose becomes effective by some means, significantly suppressing prostate cancer cell growth.

And, the same synergy can be seen throughout meals. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E located in nuts and seeds do little to inhibit seasoned-growth signaling of prostate cancer cells—much less than 10%.

But all three together suppresses increase signaling like 70%.

The entire is greater than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- sufferers with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for three weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA ranges dropped “by way of 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and extended blood degrees are mechanically used “to screen the fulfillment of [cancer] treatment.

It became surprising to find that,” in just three weeks, a “tomato sauce-based nutritional intervention” should lower PSA concentrations in guys with prostate cancer. Also, free radical harm of the DNA in their white blood cells dropped by 21%.

Imagine how antioxidant-negative their weight loss plan should have been in advance, if less than a cup of tomato sauce an afternoon should reduce DNA harm by means of more than a fifth.

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Okay, however what did they find in their prostates? “[H]uman prostate tissue [is thought to] be in particular vulnerable to oxidative DNA damage via free radicals, which might be idea to play a important function in all tiers of [cancer formation].” This may be for a number of motives, such as “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgical procedure, and resected tissues from tomato sauce-supplemented sufferers had 28% less unfastened radical harm than predicted.

Here’s the DNA harm inside the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here became no affiliation between” the level of lycopene in the prostate and the protecting results.

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Tomatoes incorporate an entire bunch of factors, a number of which may be even greater effective than lycopene.

Regardless, within contrast to the lycopene dietary supplements on my own, “the entire-food intervention” regarded to assist. To see if lycopene played any role in any respect, one would have to check a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what if you in comparison purple tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to directly lycopene within a pill?

So, they fed human beings red tomato paste, yellow tomato paste, lycopene drugs, or placebo pills, and then dripped their blood on prostate cancer cells growing in a petri dish.

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Compared to those no longer consuming anything, the purple tomato serum, the blood from people who ate purple tomato paste, considerably decreased the prostate cancer mobile’s expression of a growth-selling gene known as cyclin D1.

This downregulation of the gene by means of the red tomato intake “may additionally contribute to lower prostate most cancers danger via proscribing cellular proliferation.” The red tomato seemed to paintings higher than the yellow;

so, perhaps the lycopene helped, but now not in tablet shape. “[T]his gene become now not regulated by means of [the lycopene-pill serum],” indicating that perhaps it’s some thing else.

And, lycopene on my own appreciably upregulated “procarcinogenic genes.

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