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They were essentially denied, with the FDA announcing that the evidence was “very confined and preliminary,” and not using a endorsement allowed for ketchup or dietary supplements.

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By that time, further population reviews had forged doubt at the lycopene concept. Consumers of excessive dietary intakes of lycopene didn’t appear to have decrease cancer rates, in any case.

But, who has high nutritional intakes of lycopene?

Those that eat the maximum pizza; so, perhaps it’s no surprise there are mixed consequences.

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What we want is to place lycopene to the test.

It started out with a case statistic. A 62-12 months old guy with terminal prostate cancer;

failed surgical treatment, failed chemotherapy, metastases all over, spread to the bone.

And so, he changed into sent to hospice to die.

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So, he took it upon himself to provoke “phytotherapy”—plant-based totally remedy, taking the amount of lycopene determined within 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste every day.

His PSA, a degree of tumor bulk, started out out at 365, dropped to 140 the subsequent month, and then down to 8.

His metastases started out disappearing, and, as of his ultimate comply with-up, regarded to be living happily ever after. But, when given within better-dose tablet shape, it didn’t seem to paintings.

A 2013 evaluate of all such lycopene complement trials “did not support [the initial] optimism.” In reality, they were just satisfied that the lycopene pills didn’t become inflicting greater cancer, like beta-carotene tablets did.

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But, then got here 2014. Researchers within Italy have been giving the largest doses they might of lycopene, selenium, and isolated green tea compounds to men with precancerous prostate lesions, hoping they may save you complete-blown most cancers.

But, within 2014, the increased effects of a comparable trial had been posted, wherein selenium and vitamin E supplements ended in greater cancer.

Yikes! So, those researchers stopped their trial, and broke the code to unblind the results, And certainly, the ones taking high doses of lycopene, green tea catechins, and selenium seemed to get greater cancer than folks who just were given sugar capsules.

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“The capacity implications are dramatic,” said the lead researcher, “given the current large international use of such compounds as alleged preventive vitamins within prostate and different cancers.” What went incorrect?

Well, after the beta-carotene pill debacle, researchers measured mobile harm at specific herbal and unnatural doses of beta-carotene. At nutritional doses, beta-carotene suppressed cellular damage, but at better, supplemental doses, it not most effective appeared to prevent running, but precipitated extra harm.

And, the equal with lycopene.

“Both lycopene and [beta]-carotene afforded protection against DNA damage” at the types of ranges one would possibly see within humans consuming lots of tomatoes or candy potatoes—”stages…similar with those seen in the [blood] of those who consume a carotenoid-rich healthy weight loss program.” However, on the sort of blood concentrations that one would possibly get taking capsules, “the ability to shield the cells against such [free radical] damage was swiftly lost, and, indeed, the presence of [high levels of beta-carotene and lycopene] can also without a doubt serve to increase the volume of DNA damage.” So, no marvel excessive-dose lycopene drugs didn’t paintings.

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“Phytochemicals [may be] guardians of our fitness,” but “[t]he safety of eating focused extracts…is unknown.” The shielding blessings of a phytochemical-wealthy eating regimen is quality acquired [through whole plant foods].” The meals enterprise has specific thoughts, though.