Good Antioxidant

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But, lycopene within supplement form doesn’t look like powerful at decrease doses, either.

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“There is a robust [protective] correlation between the consumption of [actual whole] fruit[s] and greens and the occurrence of positive cancers.” But while we complement with most effective a unmarried compound isolated within tablet form, we might also disillusioned the healthful herbal balance of antioxidants. It does appear to be pretty the human hubris to think we can reproduce “the useful outcomes of eating whole fruits and greens” via giving dietary supplements of a unmarried phytochemical, which might generally engage with heaps of different compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be acknowledged “to build up in human prostate tissue.” And, “there also are severa non–carotenoid compounds within tomatoes that [may] have [anti-cancer] interest”—no longer to mention all the compounds we've yet to even symbolize.

But, it’s no longer about finding the one magic bullet: “The anti-most cancers results of carotenoids and other phytonutrients may additionally live in [their] mixed activity.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined within the majority who eat everyday quantities of tomatoes, there’s very little impact on most cancers cell boom within vitro, used one by one.

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But integrate them all together, and a non-effective dose plus a non-effective dose will become powerful someway, notably suppressing prostate most cancers cellular increase.

And, the equal synergy may be visible throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the nutrition E discovered in nuts and seeds do little to inhibit seasoned-increase signaling of prostate cancer cells—much less than 10%.

But all three collectively suppresses growth signaling like 70%.

The complete is extra than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty-two patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce every day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA levels dropped “via 17.5%.” PSA, prostate-unique antigen, is a protein produced by prostate gland cells, and accelerated blood tiers are robotically used “to screen the achievement of [cancer] treatment.

It became surprising to locate that,” in only three weeks, a “tomato sauce-based totally nutritional intervention” ought to decrease PSA concentrations in guys with prostate cancer. Also, free radical harm of the DNA of their white blood cells dropped by way of 21%.

Imagine how antioxidant-terrible their food plan should have been ahead, if less than a cup of tomato sauce an afternoon should lessen DNA harm by way of more than a fifth.

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Okay, but what did they discover of their prostates? “[H]uman prostate tissue [is thought to] be in particular at risk of oxidative DNA damage through loose radicals, which can be concept to play a critical role in all degrees of [cancer formation].” This may be for some of reasons, such as “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the three weeks of tomato sauce from the surgery, and resected tissues from tomato sauce-supplemented patients had 28% less free radical harm than anticipated.

Here’s the DNA damage within the prostate earlier than the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s exciting is that “[t]right here changed into no affiliation among” the level of lycopene within the prostate and the protecting outcomes.

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Tomatoes contain an entire bunch of things, a number of which can be even extra effective than lycopene.

Regardless, in comparison to the lycopene supplements on my own, “the entire-meals intervention” regarded to help. To see if lycopene performed any function in any respect, one could have to test a lycopene-loose tomato—within different words, a yellow tomato.

So, what in case you as compared purple tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to instantly lycopene within a tablet?

So, they fed people purple tomato paste, yellow tomato paste, lycopene tablets, or placebo capsules, after which dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to the ones no longer ingesting whatever, the red tomato serum, the blood from individuals who ate pink tomato paste, considerably reduced the prostate most cancers cellular’s expression of a increase-promoting gene known as cyclin D1.

This downregulation of the gene by using the crimson tomato consumption “may additionally make contributions to decrease prostate most cancers chance by way of proscribing cell proliferation.” The pink tomato appeared to paintings higher than the yellow;

so, perhaps the lycopene helped, but no longer within pill shape. “[T]his gene became now not regulated with the aid of [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene alone significantly upregulated “procarcinogenic genes.

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