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But, lycopene within complement form doesn’t appear like effective at lower doses, either.

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“There is a sturdy [protective] correlation among the intake of [actual whole] fruit[s] and vegetables and the prevalence of positive cancers.” But when we supplement with simplest a single compound remoted within pill form, we may additionally dissatisfied the healthful natural stability of antioxidants. It does appear to be quite the human hubris to assume we will reproduce “the beneficial results of eating whole fruits and greens” by using giving supplements of a unmarried phytochemical, which would generally interact with thousands of other compounds within “the herbal matrix” Mother Nature supposed.

In addition to lycopene, different carotenoids within tomatoes consist of beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of that are recognized “to accumulate in human prostate tissue.” And, “there also are severa non–carotenoid compounds in tomatoes that [may] have [anti-cancer] pastime”—no longer to mention all the compounds we've yet to even signify.

But, it’s no longer approximately locating the only magic bullet: “The anti-most cancers results of carotenoids and different phytonutrients may also are living within [their] blended activity.” For instance, at the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene determined in most people who consume regular quantities of tomatoes, there’s little or no impact on cancer cell growth within vitro, used one at a time.

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But integrate all of them together, and a non-powerful dose plus a non-effective dose becomes effective somehow, notably suppressing prostate cancer cell growth.

And, the equal synergy can be seen throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E located in nuts and seeds do little to inhibit pro-growth signaling of prostate most cancers cells—less than 10%.

But all three collectively suppresses boom signaling like 70%.

The whole is extra than the sum of its elements.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” were given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…earlier than their scheduled radical prostatectomy.” In their bloodstream, PSA tiers dropped “via 17.5%.” PSA, prostate-unique antigen, is a protein produced by way of prostate gland cells, and expanded blood ranges are mechanically used “to reveal the success of [cancer] treatment.

It become surprising to locate that,” in only three weeks, a “tomato sauce-based dietary intervention” should lower PSA concentrations in guys with prostate most cancers. Also, loose radical harm of the DNA in their white blood cells dropped through 21%.

Imagine how antioxidant-poor their diet have to have been in advance, if much less than a cup of tomato sauce a day could lessen DNA harm via more than a 5th.

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Okay, but what did they locate in their prostates? “[H]uman prostate tissue [is thought to] be specifically vulnerable to oxidative DNA harm by using unfastened radicals, which might be notion to play a important function in all levels of [cancer formation].” This can be for some of motives, inclusive of “fewer DNA restore enzymes.” Well, the researchers had tissue samples taken earlier than the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented sufferers had 28% less loose radical damage than anticipated.

Here’s the DNA damage in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]right here become no association among” the level of lycopene inside the prostate and the protecting results.

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Tomatoes comprise an entire bunch of things, a number of which may be even greater effective than lycopene.

Regardless, within comparison to the lycopene supplements by myself, “the complete-meals intervention” appeared to help. To see if lycopene performed any role at all, one might have to check a lycopene-free tomato—in different words, a yellow tomato.

So, what in case you in comparison crimson tomatoes to yellow tomatoes, that have all of the non-lycopene tomato compounds, to immediately lycopene in a tablet?

So, they fed people purple tomato paste, yellow tomato paste, lycopene capsules, or placebo pills, and then dripped their blood on prostate most cancers cells growing in a petri dish.

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Compared to the ones not eating whatever, the red tomato serum, the blood from people who ate purple tomato paste, considerably reduced the prostate most cancers cellular’s expression of a boom-promoting gene called cyclin D1.

This downregulation of the gene by the crimson tomato consumption “may additionally make a contribution to decrease prostate cancer risk via limiting cell proliferation.” The red tomato regarded to work higher than the yellow;

so, perhaps the lycopene helped, but no longer in tablet shape. “[T]his gene become not regulated by [the lycopene-pill serum],” indicating that perhaps it’s something else.

And, lycopene on my own substantially upregulated “procarcinogenic genes.

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