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They were basically denied, with the FDA saying that the proof changed into “very restricted and initial,” and not using a endorsement allowed for ketchup or supplements.

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By that point, similarly populace reviews had cast doubt at the lycopene idea. Consumers of excessive dietary intakes of lycopene didn’t seem to have decrease cancer shares, after all.

But, who has high dietary intakes of lycopene?

Those that eat the maximum pizza; so, perhaps it’s no surprise there are mixed results.

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What we need is to put lycopene to the test.

It began with a case study. A 62-12 months antique guy with terminal prostate cancer;

failed surgical treatment, failed chemotherapy, metastases all over, spread to the bone.

And so, he became despatched to hospice to die.

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So, he took it upon himself to provoke “phytotherapy”—plant-based totally therapy, taking the quantity of lycopene found in 1 / 4-cup of tomato sauce, or a tablespoon of tomato paste each day.

His PSA, a degree of tumor bulk, commenced out at 365, dropped to 140 the following month, and then right down to 8.

His metastases started out disappearing, and, as of his ultimate observe-up, appeared to be living fortuitously ever after. But, when given within better-dose pill shape, it didn’t seem to work.

A 2013 evaluate of all such lycopene supplement trials “did not assist [the initial] optimism.” In reality, they have been simply glad that the lycopene pills didn’t grow to be inflicting more cancer, like beta-carotene capsules did.

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But, then got here 2014. Researchers in Italy had been giving the biggest doses they may of lycopene, selenium, and remoted green tea compounds to guys with precancerous prostate lesions, hoping they may save you complete-blown cancer.

But, within 2014, the elevated results of a comparable trial have been posted, in which selenium and nutrition E dietary supplements ended in greater most cancers.

Yikes! So, these researchers stopped their trial, and broke the code to unblind the outcomes, And indeed, the ones taking excessive doses of lycopene, inexperienced tea catechins, and selenium seemed to get greater most cancers than those who simply were given sugar drugs.

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“The capability implications are dramatic,” said the lead researcher, “given the modern-day large global use of such compounds as alleged preventive vitamins within prostate and other cancers.” What went incorrect?

Well, after the beta-carotene pill debacle, researchers measured cellular damage at extraordinary natural and unnatural doses of beta-carotene. At dietary doses, beta-carotene suppressed cell damage, however at better, supplemental doses, it not handiest appeared to forestall running, however triggered extra harm.

And, the identical with lycopene.

“Both lycopene and [beta]-carotene afforded protection towards DNA harm” on the varieties of degrees one may see in people eating plenty of tomatoes or sweet potatoes—”levels…comparable with those seen within the [blood] of folks who consume a carotenoid-wealthy healthful eating regimen.” However, on the kind of blood concentrations that one would possibly get taking drugs, “the capacity to defend the cells against such [free radical] harm changed into swiftly lost, and, certainly, the presence of [high levels of beta-carotene and lycopene] may additionally clearly serve to growth the extent of DNA harm.” So, no wonder high-dose lycopene drugs didn’t paintings.

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“Phytochemicals [may be] guardians of our health,” however “[t]he safety of consuming focused extracts…is unknown.” The shielding blessings of a phytochemical-wealthy eating regimen is quality acquired [through whole plant foods].” The meals industry has exceptional ideas, though.