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But, lycopene within complement shape doesn’t appear to be powerful at decrease doses, both.

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“There is a strong [protective] correlation among the consumption of [actual whole] fruit[s] and veggies and the prevalence of sure cancers.” But when we supplement with only a unmarried compound remoted in pill form, we can also disenchanted the healthful natural stability of antioxidants. It does seem to be quite the human hubris to suppose we will reproduce “the useful results of consuming whole fruits and veggies” with the aid of giving dietary supplements of a single phytochemical, which would commonly engage with heaps of other compounds in “the herbal matrix” Mother Nature supposed.

In addition to lycopene, other carotenoids in tomatoes encompass beta-carotene, gamma-carotene, zeta-carotene, phytofluene, and phytoene, all of which can be recognized “to build up within human prostate tissue.” And, “there are also numerous non–carotenoid compounds in tomatoes that [may] have [anti-cancer] hobby”—no longer to mention all the compounds we've got but to even signify.

But, it’s not about finding the one magic bullet: “The anti-most cancers effects of carotenoids and different phytonutrients can also are living in [their] blended interest.” For instance, on the low concentrations of the tomato compounds phytoene, phytofluene, and lycopene observed in most people who devour normal quantities of tomatoes, there’s very little effect on most cancers cell increase in vitro, used separately.

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But integrate all of them together, and a non-effective dose plus a non-powerful dose turns into powerful someway, extensively suppressing prostate most cancers cellular increase.

And, the identical synergy may be visible throughout ingredients. Curcumin, the yellow pigment within turmeric and curry powder, tomato extracts, and the diet E located within nuts and seeds do little to inhibit pro-increase signaling of prostate most cancers cells—much less than 10%.

But all three together suppresses growth signaling like 70%.

The entire is extra than the sum of its components.

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So, How About Instead Of Giving Cancer Patients Lycopene Pills, We Give Them Some Tomato Sauce?

“Thirty- patients with localized prostate [cancer]” had been given three-quarters of a cup of canned tomato sauce each day “for 3 weeks…before their scheduled radical prostatectomy.” In their bloodstream, PSA stages dropped “by means of 17.5%.” PSA, prostate-particular antigen, is a protein produced with the aid of prostate gland cells, and accelerated blood stages are routinely used “to monitor the achievement of [cancer] treatment.

It was surprising to locate that,” in just three weeks, a “tomato sauce-based totally nutritional intervention” may want to lower PSA concentrations within guys with prostate most cancers. Also, free radical harm of the DNA in their white blood cells dropped through 21%.

Imagine how antioxidant-terrible their weight loss plan must were in advance, if less than a cup of tomato sauce an afternoon may want to lessen DNA harm via more than a fifth.

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Okay, however what did they find in their prostates? “[H]uman prostate tissue [is thought to] be particularly at risk of oxidative DNA harm through free radicals, which might be idea to play a essential role within all levels of [cancer formation].” This can be for some of motives, together with “fewer DNA repair enzymes.” Well, the researchers had tissue samples taken before the tomato sauce from biopsies, and tissue samples after the 3 weeks of tomato sauce from the surgical operation, and resected tissues from tomato sauce-supplemented patients had 28% less free radical damage than anticipated.

Here’s the DNA damage in the prostate before the tomato sauce, and right here’s after.

Just 20 days of sauce. And, what’s interesting is that “[t]here became no association between” the extent of lycopene in the prostate and the protective outcomes.

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Tomatoes include a whole bunch of factors, a number of which can be even more powerful than lycopene.

Regardless, in assessment to the lycopene dietary supplements alone, “the entire-food intervention” regarded to assist. To see if lycopene performed any role at all, one could have to check a lycopene-loose tomato—within different phrases, a yellow tomato.

So, what in case you as compared red tomatoes to yellow tomatoes, which have all of the non-lycopene tomato compounds, to straight lycopene within a pill?

So, they fed human beings crimson tomato paste, yellow tomato paste, lycopene tablets, or placebo drugs, after which dripped their blood on prostate most cancers cells developing within a petri dish.

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Compared to those now not ingesting something, the crimson tomato serum, the blood from individuals who ate red tomato paste, appreciably reduced the prostate cancer cellular’s expression of a increase-selling gene called cyclin D1.

This downregulation of the gene by way of the crimson tomato intake “may make contributions to lower prostate most cancers risk by proscribing cellular proliferation.” The purple tomato regarded to paintings higher than the yellow;

so, perhaps the lycopene helped, but now not in tablet form. “[T]his gene became now not regulated by using [the lycopene-pill serum],” indicating that maybe it’s some thing else.

And, lycopene alone appreciably upregulated “procarcinogenic genes.

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